Rosuvastatin tablets and aspirin can be taken at the same time. Their mechanisms of action are different and do not conflict with each other, and simultaneous administration does not increase the risk of adverse reactions. Rosuvastatin is a statin lipid-regulating drug, the main mechanism of action is to inhibit hepatic cholesterol synthesis and reduce endogenous cholesterol production, mainly used for hyperlipidemia with elevated cholesterol. Its main adverse reactions include elevated blood glucose, headache and dizziness, abdominal pain and nausea, myalgia, rash and pruritus. It is contraindicated in patients with severe hepatic and renal impairment, patients with myopathy, pregnant and lactating women. Aspirin mainly through the inhibition of cyclooxygenase activity and reduce the synthesis of thromboxane A2, play the role of inhibiting platelet aggregation, mainly used in cardiovascular disease and the prevention of thrombosis after surgery. The main adverse reactions are gastrointestinal reactions and allergic reactions. It is contraindicated in patients with gastrointestinal bleeding, thrombocytopenia, hemophilia, as well as in patients with hypersensitivity to the components of the drug. The combination of Rosuvastatin and aspirin is mainly used in the treatment of coronary heart disease, which can stabilize atherosclerotic plaques, delay the progression of the disease, as well as prevent the rupture of atherosclerotic plaques and thrombosis, avoiding the occurrence of acute cardiovascular events. If you need to use the above drugs, you need to standardize the use under the guidance of a doctor to avoid adverse consequences.