A soft plaque shadow within a blood vessel is the presence of a soft-textured plaque within the examined blood vessel, indicating that the plaque has formed over a relatively short period of time, is less stable, and is prone to dislodgement. Soft plaque shadow in the blood vessel is relative to hard plaque; soft plaque is usually unstable, usually formed in a relatively short period of time, and is prone to dislodge and form a thrombus or embolism, leading to an increased risk of damage to vital organs, so patients need to pay more attention. Plaque is mainly due to arterial vascular endothelial damage, damage caused by inflammatory cells as well as lipid deposits causing subendothelial hemorrhage, and over time, subendothelial calcification will occur. Patients who check for soft plaque shadows in the blood vessels should go to the internal medicine department of the hospital in time and cooperate with the treatment under the doctor’s guidance so as not to affect their personal health.