The azole drugs do not necessarily evolve into atrophic gastritis, the use of medication individuals also have certain individual differences, can not be judged from time to time. The azoles are proton pump inhibitors, such as omeprazole, lansoprazole, etc. They are mainly used for the treatment of heartburn and acid reflux caused by excessive secretion of gastric acid, and can be used for the treatment of gastritis, gastric ulcers, duodenal ulcers and other diseases. The main adverse effects of proton pump inhibitors are headache, nausea, vomiting, constipation, drowsiness, sleep disorders, rash, urticaria, liver function abnormalities. This kind of drugs pay attention to the use of patients who are allergic to the product can not take serious, hepatic insufficiency and renal insufficiency patients, infants and young children to avoid the use of such drugs. In clinical practice, long-term use may lead to the formation of atrophic gastritis, but the incidence is low, and how long the medication will develop into atrophic gastritis time is uncertain. Oral azole drugs, it is recommended that patients consult the gastroenterology department of a regular hospital. If there is any discomfort, you should seek medical attention.