Thickening of gallbladder wall can be caused by benign and malignant lesions, if malignant lesions, thickening 19mm*12mm is more serious. 1. Benign lesions: Thickening of the gallbladder wall can be caused by benign lesions such as cholecystitis, gallbladder stones, gallbladder adenomyosis and other diseases. Gallbladder wall thickening of 19mm*12mm is not serious, but it needs to be surgically removed. 2. Malignant lesions: gallbladder wall thickening 19mm * 12mm is more serious, should also be suspected of gallbladder malignancy. If ultrasound, enhanced CT, magnetic resonance imaging examination found that the boundaries between the gallbladder and the surrounding tissues are not clear, the mucosa of the gallbladder is not intact, and there is a mass invading the wall of the gallbladder, etc., then there should be a high degree of suspicion of carcinoma, which can be dangerous to life. If pathological examination finds malignant tumor, the diagnosis can be confirmed, and the situation is more serious. It is recommended that patients go to the hospital in time to improve the relevant examination, to clarify the cause of gallbladder wall thickening, and timely treatment under the guidance of the doctor, so as not to delay the condition.