Elevated pepsinogen Ⅰ suggests increased gastric acid secretion, there may be the possibility of chronic gastritis or Helicobacter pylori infection, acid suppression therapy, anti-Helicobacter pylori therapy is required. When pepsinogen Ⅰ is elevated, it suggests that the main cell hypersecretion function, gastric acid secretion increases, the patient may have chronic gastritis or Helicobacter pylori infection, and needs to be diagnosed by gastroscopy and Helicobacter pylori test. 1. Acid-suppressing treatment: commonly used drugs include omeprazole enteric-coated capsules and ranitidine. 2. If infected with Helicobacter pylori, four combinations of drugs are needed for antimicrobial treatment, i.e., omeprazole + bismuth potassium citrate + furazolidone + clarithromycin. 3. Daily life usually need to drink more water, diet should be regular, pay attention to do not eat stimulation, greasy, spicy food. It is recommended to actively go to the hospital, clear diagnosis, under the doctor’s instructions to use medication, do not self-medication, so as not to delay the condition.