Muscle soreness on the front side of the thigh is mainly caused by diseases such as quadriceps disease, femoral neuritis and nerve entrapment. Reasonable treatments need to be used for different diseases. 1. Quadriceps disease: pain in the front of the thigh is often caused by the front side of the thigh of the quadriceps muscle strain or strain injury, such as running or strenuous exercise can lead to severe pain in the front of the thigh. Treatment can use rest, physical therapy and hot compresses. 2. Femoral neuritis: aseptic inflammation of the femoral nerve caused by cold stimulation, cold, extrusion, etc., resulting in edema of the bony nerves in the inguinal outlet, causing pain and numbness in the muscles of the anterior thigh. Treatment can take vitamin B and methylcobalamin. 3. Nerve compression: common lumbar disc herniation or femoral nerve, lateral femoral cutaneous nerve compression, etc., may produce radiating pain. Non-steroidal anti-inflammatory drugs such as Celecoxib and Ibuprofen can be taken. Serious conditions can be treated surgically. Appears the front side of the thigh soreness if the long-term does not relieve. Need to go to the regular hospital to find the cause of reasonable treatment.