Multiple metastases in advanced stage of breast cancer can be treated by symptomatic treatment, chemotherapy, targeted therapy radiotherapy and endocrine therapy as prescribed by doctors. 1. Symptomatic treatment: some patients with advanced breast cancer will have pain and pressure pain in the vertebral area of the back. Patients can take oral analgesic drugs under doctor’s guidance, such as morphine sulfate, ibuprofen and so on. 2. Chemotherapy: as multiple metastases in advanced stage of breast cancer may miss the best time for surgical treatment, usually chemotherapy drugs can be used for treatment, such as cyclophosphamide, fluorouracil, etc. under the guidance of doctors. 3. Targeted drug therapy: Targeted drug therapy is also an important therapeutic means for breast cancer metastasis treatment. Targeted drug therapy, such as Trastuzumab, Lapatinib, etc., can be used under doctor’s advice, which can control the metastasis of cancer cells. 4. Radiotherapy: including adjuvant radiotherapy, palliative radiotherapy and other methods, which can be chosen according to specific conditions. 5. Endocrine therapy: endocrine therapy drugs include tamoxifen, letrozole, anastrozole, exemestane and so on. Specific drug selection and treatment program should follow the doctor’s instructions. The above drugs are recommended to patients under the guidance of a doctor, not blindly self-medication, it is recommended that the patient to relax and actively treat, to avoid aggravating the condition.