Early syphilis is mainly manifested as hard chancre. The main clinical manifestation of early syphilis is the symptom of early syphilis, which is mainly manifested by the appearance of hard ulcers without pain, itching and other self-conscious symptoms on the skin and mucous membranes infected by syphilis, with a small amount of plasma secretion on them, and is often accompanied by swollen lymph nodes around the patient, and so on. The hard chancre begins as a small red spot on the external genitalia, mostly on the penis, glans and prepuce in men, and on the labia and perineum in women. Patients usually begin to experience localized symptoms about 2-3 weeks after being infected with the syphilis spirochete, and there are usually no systemic symptoms in the early stages. Stage 2 syphilis can also present with syphilis rash, flat warts and other manifestations. Syphilis rash is mainly manifested as a generalized rose rash or brown round, oval rash, usually no itching, the rash is not fused with each other. It occurs on the trunk, limbs, scrotum, perineum, anus, groin area. Flat warts are mainly oval and irregularly shaped smooth surface plasmacytoid papules. The skin manifestation of syphilis is very complex, the patient has the above symptoms to pay attention to, timely to the specialized hospital actively cooperate with the diagnosis and treatment, so as not to delay the condition.