Most rheumatic diseases are systemic diseases that can involve multiple organs and systems throughout the body and have high disability and mortality rates if not treated in a timely manner. They include: systemic lupus erythematosus, rheumatoid arthritis, dry syndrome, ankylosing spondylitis, gout, osteoarthritis (commonly known as osteophytes), psoriatic arthritis, adult still disease, polymyositis/dermatomyositis, aortitis, leukodystrophy, ANCA-associated vasculitis, scleroderma, rheumatic polymyalgia, lipofuscinosis, recurrent polychondritis, autoimmune liver disease, IgG4-related diseases, etc. I. Which symptoms should be suspected of rheumatism 1. unexplained fever: fever without anti-infection and evidence of tumor should be aware of the possibility of rheumatism. 2, skin mucosa: facial butterfly-shaped erythema, frostbite rash, red skin rash after sun exposure, significantly more hair loss than before, oral ulcers, vulvar ulcers, purpura or painful erythema of lower extremities, pseudofolliculitis, pustular rash, needle eye redness or even pus for more than 2 days, reticular bruises, periorbital erythema, red rash on the forehead and shoulders and neck, desquamative rash on joint extensions, skin tightening and hardening, etc. 3, joint pain: symmetric swelling and pain in the wrist, metacarpophalangeal joint, proximal interphalangeal joint, elbow joint, knee joint, ankle joint and pain in the temporomandibular joint with open mouth are likely to be rheumatoid arthritis; pain in the distal interphalangeal joint and knee joint after activity should be considered osteoarthritis; sudden unilateral swelling and pain at the root of the big toe or the back of the foot and ankle often suggest gout; lower back pain, alternating hip pain, heel pain, hunchback need Ankylosing spondylitis should be alerted. 4. Morning stiffness: stiffness and adhesion of the lower back and joints after waking up in the morning, which affects turning over and fist clenching and is relieved after activity. 5, Raynaud’s phenomenon: hands or feet appear white when cold or emotional excitement, then purple, red, may be accompanied by numbness, pain in the hands and feet. 6.Dry mouth, dry eyes, dry skin: It may be dry syndrome, manifested as less saliva, red tongue with less moss, more cavities, fragmented tooth loss, severe cases need to be served with water when entering dry food, dry eyes, less tears or no tears when crying, dry, itchy and flaky skin. 7.Muscle pain and muscle weakness: especially muscle pain and weakness of limbs, difficulty in standing up after squatting, difficulty in raising arms, etc., which can be seen in myositis, rheumatic polymyalgia, etc. 8, thrombosis: repeated spontaneous abortion, unexplained deep vein thrombosis of the lower extremities or pulmonary embolism, cerebral infarction, etc. should be alert to antiphospholipid syndrome. 9, eye, ear, nose and throat symptoms: recurrent ophthalmia, blurred vision, recurrent auricular redness and pain, nasal bridge collapse, allergic rhinitis with or without asthma, sinusitis, all may be manifestations of rheumatic diseases. 10, multi-system, multi-organ lesions: such as respiratory, digestive, neurological, cardiac, kidney and other multiple systems or organs should be alerted to rheumatic disease when problems arise. Second, which tests should be noted to exclude rheumatism when abnormal Blood tests show decreased white blood cells and platelets, anemia, eosinophilia, positive urine protein or urine occult blood, elevated blood creatinine, elevated blood uric acid, elevated muscle enzymes, excessive difference in blood pressure in both arms, weakened or absent pulse, enlarged liver, spleen and lymph nodes, unexplained cirrhosis, interstitial pneumonia, immobilized lung shadow, non-tumor masses in the lungs, and narrowing of the tracheal lumen, etc., may be clues to the diagnosis of rheumatic disease. If you have any of the above symptoms or abnormal examination, please visit the Department of Rheumatology and Immunology to avoid delaying the treatment and causing serious consequences!