Methods of removing frown lines include surgical treatments, topical fillers, botulinum toxin injections, and physical therapy. The lines are two lines extending down the side of the nose, mostly due to over-expression or loss of collagen in the skin. 1. Surgery: Facelift can be used to remove wrinkles by lifting the facial skin backward and removing the excess. 2. Local fillers: Hyaluronic acid and autologous fat can be used to fill in the subcutaneous depressions of the wrinkles to make the skin fuller and more elastic, thus improving the wrinkles and rejuvenating the skin. 3. Botulinum toxin injection: Botulinum toxin can inhibit the release of acetylcholine from the neuromuscular junction, block the nerve impulses between the nerve and the muscle, and make the contracted muscles relax, so as to achieve the purpose of removing wrinkles. 4. Physical therapy: generally through radio frequency, ultrasonic knife and other photoelectric treatment, stimulate the local collagen proliferation, so as to achieve the purpose of wrinkle. It is recommended that patients go to regular hospitals and follow the doctor’s instructions to choose the appropriate treatment to improve the wrinkles. Usually try to minimize facial expression to reduce the appearance of wrinkles.