Benign gastric diseases can be survived for a long time by total gastrectomy, and the life expectancy of patients with malignant tumors of the stomach after total gastrectomy depends on the benign and malignant nature of the disease; benign can basically be cured, and malignant mainly depends on the tumor staging and so on. Some reports show that: 1, 2, 3, 5-year overall survival rate of gastric cancer patients with total gastrectomy is 61.1%, 44.1%, 38.8%, 11.1% respectively; while three-year survival rate of stage I, II, III, and IV is 100%, 60%, 25%, and 0; and 5-year survival rate of stage I is 66.7%. After total gastrectomy the digestive tract of the esophagus and jejunum is anastomosed and reconstructed, and the incision is well cared for to prevent infection and to be fed with fluids or semi-fluids, and normal diet is resumed after the body slowly recovers. After the operation, chemotherapy (such as 5-FU, cisplatin, mitomycin, etc.) should be given according to the condition of the disease and under the prescription of the oncologist. After total gastrectomy, regular gastroscopy is the key to early diagnosis of residual gastric cancer. Patients should adopt reasonable operation mode according to their conditions, take regular diet, strengthen exercise, keep physical and mental well-being, and standardize the treatment in time to avoid delaying the disease.