Sudden epigastric pain in the middle of the night need to be treated according to the cause of the disease, generally common causes are duodenal bulbous ulcer, cholecystitis, acute attack of chronic gastritis, etc., to take the treatment includes general treatment, medication and so on. 1. Duodenal bulbous ulcer: the vagus nerve excitability increases in the middle of the night, which will cause an increase in gastric acid secretion, thus triggering the duodenal bulbous ulcer to occur pain symptoms. The clinical symptoms of duodenal bulbous ulcers are mainly epigastric pain, fasting pain, pain attacks, eating some food can reduce. Can also take drugs pantoprazole, omeprazole, etc.. 2. Cholecystitis: the incidence is relatively high. Patients can have pain, fever, nausea, acid reflux, abdominal distension and other phenomena, jaundice can occur. You can apply hot compresses to the local area and take oral medicines such as scopolamine and drotaverine hydrochloride. 3. Acute exacerbation of chronic gastritis: recurring epigastric pain during sleep for years, manifested as vague pain, hidden pain or colic, and no further aggravation of the degree of pain in the recent past. Can take drugs omeprazole, pantoprazole, etc.. Lead to sleep in the middle of the night suddenly epigastric pain may also have other causes such as intestinal spasm, it is recommended to visit the hospital in a timely manner to identify the cause of the disease, under the guidance of the doctor to give the corresponding treatment and treatment, the above drugs need to be under the guidance of the doctor to use the drug.