In general, the use of constipation Keserol is to open the sealing end, first squeeze out a little liquid lubrication opening, the patient to take the side position and relax, so that the external anal sphincter to maintain a state of relaxation, by family members, nurses or the patient himself or herself will be gently inserted into the anus Keserol front, the bottle of liquid all the liquid squeezed into the rectum and retained for 10-15 minutes before defecation. Keserol is a colorless clarified viscous liquid containing glycerin, belongs to the lubricating laxative, the drug is not absorbed after injecting into the rectum, can lubricate and stimulate the intestinal wall, soften the stool so that it is easy to discharge. It is mainly used for the treatment and improvement of constipation, and can also be used for the prevention and treatment of chapped hands and feet. It is contraindicated in patients with allergy to Keselen, intestinal perforation, severe abdominal pain, hemorrhoids with bleeding. Improper use of Corkscrew may cause bleeding from anal and rectal mucosal injury. When the use of Coca-Cola does not improve the difficulty in defecation, it is recommended to go to the hospital for further consultation.