Ankylosis generally refers to ankylosing spondylitis, the father is ankylosing spondylitis son hereditary odds can not be generalized, there is a lack of relevant information. Ankylosing spondylitis is considered to be a polygenic genetic disease caused by genetic and environmental factors, in which the main susceptibility gene is HLA-B27, if the father suffers from ankylosing spondylitis, the son of ankylosing spondylitis hereditary chances of how much is not clear, but the father of ankylosing spondylitis, the son of the hereditary need to be based on the individual’s situation to determine whether or not. The chances of a son inheriting ankylosing spondylitis can’t be generalized. It is recommended that patients with a family history of ankylosing spondylitis should go to the hospital for regular checkups, pay attention to warmth, and should not be in a cold and wet environment for a long time, or sit for a long time, so as to avoid triggering ankylosing spondylitis. Patients with ankylosing spondylitis are advised to seek timely medical treatment and follow the doctor’s instructions.