Pepsin test should be pepsinogen test, which can reflect the morphology and function of gastric mucosa in different parts of the stomach. Pepsinogen is the precursor of pepsin, a digestive enzyme secreted by the main cells of the stomach that participates in digestion. It can be used for the initial screening of gastric cancer screening, screening of gastric ulcer, atrophic gastritis, and Helicobacter pylori infection, and can also be used to dynamically monitor the state of change of the gastric mucosa. Pepsinogen is divided into pepsinogen I and pepsinogen II. Pepsinogen I is an indication for detecting the function of gastric secretory gland cells, while pepsinogen II is more relevant to gastric fundus mucosa lesions, so the combined detection of pepsinogen I and II has certain clinical significance for screening and auxiliary diagnosis of gastric diseases. When the results are abnormal, it is necessary to actively consult the doctor and follow the doctor’s instructions for reasonable treatment.