Penicillin is a kind of antibiotic, the use of penicillin infusion is mostly in 7~14 days, it is recommended to follow the doctor’s prescription. Penicillin is a common antibiotic in clinic, hemolytic streptococcus, streptococcus pneumoniae, etc. are sensitive to penicillin and can achieve effective antibacterial effect. If the patient’s infection is relatively mild, the use of penicillin infusion time is relatively short, may be about 7 days. If the patient’s infection is serious, the duration of the medication needs to be extended appropriately, possibly around 14 days. For patients with a history of allergy to penicillins and a positive penicillin skin test, penicillin needs to be contraindicated. Among the adverse reactions to penicillin, allergic reactions are more common, and patients are prone to skin rashes, dyspnea and other symptoms. Once an allergic reaction occurs, it needs to be treated promptly with oxygen, application of epinephrine, glucocorticoid, etc. to prevent accidents. As long-term application of penicillin and other antibiotics will induce the body to develop drug resistance, so the use of medication need to be regular medical checkups, so that according to changes in the condition of the doctor’s orders to adjust the dosage of antibiotics or replacement of other antibiotic treatments, do not indiscriminate use of drugs.