Drinking alcohol after taking cephalosporins can trigger a disulfiram-like reaction. Cephalosporin drugs will inhibit the enzyme acetaldehyde dehydrogenase, resulting in incomplete metabolism of alcohol in the body, acetaldehyde accumulation in the body, resulting in generalized flushing, headache and dizziness, drowsiness, hallucinations, nausea and vomiting, blood pressure drop and other reactions, which in severe cases can lead to confusion and respiratory distress. Patients with the above symptoms should lie down immediately. If a small amount of alcohol is ingested by mistake and the symptoms are mild, a large amount of water can be quoted to speed up the excretion of alcohol; if the symptoms are severe, with facial flushing, conjunctival congestion, dizziness, respiratory distress, etc., the patient may die of shock, and immediate medical attention should be sought. Oxygen should be given immediately when available, and the treatment drugs can be chosen from dexamethasone for anti-inflammatory and naloxone for antagonizing alcohol. The patient’s medication must strictly follow the doctor’s instructions, and should seek immediate medical attention in the event of an accident.