Early and intermediate Down’s syndrome screening are both risk assessments for Down’s syndrome babies, there is no absolute which one is more accurate, no matter which one is abnormal, further tests are needed to rule out fetal malformations. Early Down’s syndrome screening is also known as the NT test, which examines the thickness of the fetal nuchal translucency through ultrasound. If the NT value is greater than 2.5mm, it is considered abnormal, and further testing is needed to determine whether the fetus has malformations through amniocentesis. The mid-term Down’s syndrome test is to check the risk of Down’s syndrome by drawing venous blood on an empty stomach, and if the risk is critical or high, then further amniocentesis is needed to rule out fetal malformations. Early and mid-term Down screening are not more accurate, they are just tests to rule out fetal malformations in different weeks of pregnancy. It is necessary to be under the supervision of a doctor during pregnancy to make sure that the fetus is developing normally.