Syphilis may appear on the face as a syphilis rash, nodular syphilis rash, and syphilitic dendritis. Syphilis is a sexually transmitted disease caused by infection with the syphilis spirochete. According to the course of the disease, syphilis is divided into three phases, and its clinical manifestations are gradually aggravated: Phase I syphilis, usually lesions are located in the external genitalia, usually no symptoms on the face; Phase II syphilis, syphilis rash may appear on the face, etc.; Phase III syphilis, nodular syphilis rash, syphilitic gumbo, etc. may appear on the face. 1. Syphilis rash: one of the clinical manifestations of stage 2 syphilis, which may appear on the face. It is often characterized by red or reddish-brown macules, macules, plaques or scaly lesions, and may also appear as pustules and ulcers. 2. Nodular syphilis rash: one of the clinical manifestations of stage III syphilis, the damage can appear on the face. It is often manifested as copper-red infiltrative nodules of different sizes arranged in clusters, and the surface is flaky or necrotic or ulcerated, and there are usually no conscious symptoms. 3. Syphilitic gumbo: it is a sign of stage III syphilis and the most destructive kind of damage for syphilis. Typical performance for 2 ~ 10cm horseshoe-shaped ulceration, sharp edges, the surface of the sticky gum-like secretion. If the syphilitic gumbo invades the nose, it can lead to nasal rupture and collapse of the bridge of the nose, and individual patients may form syphilitic saddle nose. It is recommended that patients with syphilis should go to regular hospitals as soon as possible for examination and treatment, and follow the doctor’s instructions for standardized treatment.