Cholesterol 6.5 generally refers to the total cholesterol 6.5mmol/L, is high, is considered to be hypercholesterolemia, the patient needs to comply with the doctor’s instructions for drug treatment, general measures, etc., and also need to carry out surgical treatment if necessary. 1. Medication: Usually, patients need to follow the doctor’s instructions to use statins such as simvastatin and atorvastatin, and also need to use cholesterol absorption inhibitors such as ezetimibe. Some patients may also use bile acid sequestering agents such as colestipol and colesevelam. 2. General measures: patients usually need to control the diet, limit the intake of cholesterol, saturated fatty acids and carbohydrates, and increase physical exercise. Patients also need to develop good living habits, quit smoking and drinking in time to avoid aggravation of the disease. 3. Surgery: If the patient’s condition is more serious, or if the patient can not tolerate the medication, the patient should choose to undergo portal vena cava shunt, liver transplantation, partial ileocecal resection and so on under the guidance of the doctor. It is recommended that patients with total cholesterol of 6.5mmol/L should actively cooperate with doctors for systematic treatment so as not to delay the condition.