The differences between Niu Huang Qing Xin Wan and Niu Huang Shang Qing Wan are different drug composition, different efficacy and main treatment, and different precautions. Niu Huang Qing Xin Wan is composed of artificial oxalis, angelica sinensis, chuanxiong, licorice, Chinese yam, scutellaria baicalensis, fried bitter almonds and other drugs, the efficacy of which is to clear the heart, resolve phlegm, suppress shock and dispel wind, the main treatment for dizziness caused by wind and phlegm obstruction of the orifices, phlegm and salivary congestion (abnormal phlegm, excessive production of saliva), confusion, speech, and convulsions and seizures, seizures (pediatric disorders characterized by fainting, convulsions, convulsions). Niu Huang Shang Qing Wan is composed of artificial Niu Huang, mint, chrysanthemum, Thornybush, Angelica dahurica, Rhizoma Ligustici Chuanxiong, Gardenia, Rhizoma Coptidis, Cyperus rotundus and other medicines, the efficacy of which is to clear away heat and diarrhea of fire (clearing away the body’s heat evils and fire evils), dispersing wind and relieving pain, and is mainly used in treating the diseases caused by internal heat and toxicity, wind and fire attacking the body, such as headache and dizziness, redness in the eyes and tinnitus in the ears, swelling of the throat, sores of the mouth and tongue, swollen and painful gums and dryness of the stool. Niuhuang Qingxin Pill after taking medication occasionally have adverse reactions of skin allergies, allergic to the ingredients of the drug is prohibited, pregnant women and athletes should be cautious. Adverse reactions and contraindications of Niu Huang Qing Xin Wan are not clear. Taking the above two drugs to treat related diseases, need to be taken under the guidance of a traditional Chinese medicine practitioner, do not take blindly.