Glutamyl transpeptidase 130, suggesting elevated glutamyl transpeptidase, may be caused by physiological factors such as staying up all night, or pathologic factors such as intrahepatic bile duct stones, viral hepatitis, etc. It can be treated by lifestyle modification, drugs such as entecavir, and endoscopic retrograde cholangiopancreatography to remove stones. 1. Physiological factors: staying up late, drinking alcohol, strenuous exercise, etc. can lead to elevated serum glutamyl transpeptidase, which can be lowered through regular work and rest, avoiding staying up late, as well as lifestyle adjustments such as abstaining from cigarettes and alcohol and taking a light diet. 2. Pathologic factors: (1) Intrahepatic bile duct stones: parasites, biliary tract infections, biliary stasis, etc., can cause intrahepatic bile duct stones, abdominal pain, high fever, chills, etc., which can be removed by incision through surgical procedures such as transendoscopic retrograde cholangiopancreatography and percutaneous transcholangioscopic treatment. (2) Viral hepatitis: it is a group of systemic infectious diseases caused by hepatitis virus with liver damage as the main manifestation, and symptoms such as fatigue, loss of appetite and jaundice may appear. Interferon, lamivudine, entecavir, tenofovir and other drugs can be chosen for treatment. Glutamyl transpeptidase 130, it is recommended to consult a doctor in order to clarify the diagnosis, under the guidance of the doctor for targeted treatment.