There is no such thing as the fastest medicine for treating toothache. Medicines commonly used for pain relief include cephalosporin antibiotics, nitroimidazole antibiotics, and non-steroidal anti-inflammatory drugs such as cefprozil, metronidazole, and ibuprofen extended-release tablets. 1. Cephalosporin antibiotics: they are broad-spectrum antibiotics, mainly treating infections caused by streptococcus, staphylococcus aureus and other pathogenic bacteria, and can relieve pain caused by most types of dental and periodontal-related diseases, and common drugs include cefprozil, cefaclor and cefixime. Alcohol is prohibited while taking the medication, and should be used with caution during pregnancy and lactation. Adverse reactions such as gastrointestinal tract are common, relieved after stopping the drug. 2. Nitroimidazole antibiotics: oral some infectious diseases are often combined with a large number of anaerobic infections in the late stage, the drugs can be used for treatment, such as metronidazole, ornidazole, tinidazole. Need to ban alcohol during the drug, common gastrointestinal and neurological adverse reactions, relieve after stopping the drug. 3. Non-steroidal anti-inflammatory drugs: mainly used for antipyretic and analgesic, such as ibuprofen extended-release tablets; peptic ulcer patients with caution. Not all toothache can be relieved with drugs, such as acute pulpitis, usually drugs do not have any effect; it is recommended that patients with discomfort as soon as possible, under the guidance of the physician, clear reasons for the targeted treatment, not blindly use their own medication, so as not to delay the condition.