Long-term use of felodipine may have side effects such as facial flushing, abdominal pain and urticaria. 1. Facial flushing: Felodipine is a kind of calcium antagonist, after taking it can effectively dilate blood vessels, some people will have facial vasodilatation after taking the drug, there may be abnormal facial flushing, accompanied by local burning sensation. 2. Abdominal pain: felodipine may also have a stimulating effect on the smooth muscle of the digestive tract, there may be abdominal pain after taking the drug, and may be accompanied by constipation, abdominal distension, nausea and other abnormal symptoms. 3. Urticaria: A small number of people taking felodipine may also develop urticaria, which may form pimple-like lesions on the surface of the skin, itchy, painful and other manifestations. 4. Other side effects may include panic, dizziness, fatigue, gingivitis, hyperglycemia, etc. These reactions tend to be transient or have been reported in only a few cases. Side effects of Felodipine should be actively observed during the course of taking the drug. If the side effects continue to worsen, seek medical advice promptly and adjust the drug under the guidance of the doctor.