Urethritis medication is not effective, it may be that the bacteria are resistant to the drug, or taking drugs do not work on the bacteria, you should add or replace the drug. UTI is a kind of urinary tract infectious disease, its main clinical manifestations are frequent urination, urgent urination, painful urination. UTI is mostly caused by bacterial infection. For people who take medication for UTI, it is possible that the bacteria are resistant to the medication used, or that a single medication is unable to control the bacterial infection, or that the medication does not work on the bacteria. For bacterial tolerance or failure to choose the right drug, it is recommended to change to other antibacterial drugs, preferably according to the results of drug sensitivity tests; for a single drug can not control the situation, it is recommended to use a combination of drugs. For people with these conditions, it is recommended to consult a doctor in time to identify the cause of the disease and treat it as soon as possible.