At present, there are many sugar lovers and family members who believe that once they use insulin, they will form a dependency and can no longer switch to oral hypoglycemic drugs, and that taking oral hypoglycemic drugs again will become ineffective. Some people even believe that with insulin, the disease is hopeless. It seems that there are quite a few misconceptions about insulin. Is insulin addictive? Insulin itself is a hormone normally secreted by the body. There is no dependence and no addiction to insulin use. Deciding whether you need insulin for a long time depends on your own islet cell function and has nothing to do with insulin. Some glucose patients do have to inject insulin for life, and the reason why they cannot be withdrawn after insulin injection is because their own islet secretion function has been severely depleted, and insulin supplementation is necessary for their condition. Type 1 glucose patients must receive insulin therapy for life to ensure the metabolic needs of the body because of the complete failure of pancreatic islet function; in the advanced stage of type 2 diabetes, the patient’s pancreatic islet function tends to fail, and in this case, insulin is also needed for life. Is insulin used only when the disease is very severe? When do diabetics need insulin for treatment? For type 1 diabetes there may not be much disagreement. However, for type 2 diabetes, especially for some diabetics who have difficulty in clinical staging, it can sometimes be difficult to make a decision. The following is a brief description of when insulin therapy needs to be considered: (1) Type 1 diabetes requires insulin therapy once diagnosed due to the impaired function of its own pancreatic beta cells and absolute deficiency of insulin secretion, and lifelong insulin replacement therapy is required. (2) Type 2 diabetes is treated with a combination of lifestyle and oral hypoglycemic drugs, and if the blood glucose still does not reach the control goal, the combination of oral drugs and insulin therapy can be started. (3) Patients with diabetes mellitus with new onset and difficult to identify with type 1 diabetes mellitus can be considered for early treatment with insulin. (4) For patients with initial type 2 diabetes with high blood glucose, such as those with glycated hemoglobin greater than 9%. Because hyperglycemia has cytotoxic effect and can accelerate the apoptosis of β-cells, while rapidly relieving the toxic effect of hyperglycemia can reduce insulin resistance and even partially reverse β-cell function, so many professors suggest that type 2 diabetes with significant hyperglycemia can be treated with insulin intensive therapy for a short period of time, usually 2 weeks to 3 months. (5) In the perioperative period, especially in medium and large surgeries, which require prolonged fasting, insulin therapy is beneficial to the stabilization and adjustment of blood glucose and wound healing. (6) Serious acute complications such as diabetic ketoacidosis, diabetic hyperosmolar coma, etc., as well as in some traumatic and stressful states can be used insulin for a short time. (7) Long duration of diabetes mellitus, insulin deficiency and serious chronic complications such as diabetic foot, diabetic nephropathy and renal insufficiency also need insulin therapy. (8) Women with gestational diabetes and diabetes combined with pregnancy are generally treated with insulin. The above list is only the general situation, specific to each patient time selection will be different, need to specific analysis of the problem. Although, diabetic patients need to control blood sugar through drugs, but for patients with type 2 diabetes caused by obesity, it is a better choice to reduce the weight burden while playing insulin. (1) High weight people will reduce the efficiency of insulin. (2) Injecting too much insulin tends to cause hypoglycemia. Injecting insulin: promote cellular uptake and utilization of glucose synthesis; promote fatty acid synthesis and storage reduce lipolysis. Therefore, it is easy to have the phenomenon that the more insulin is injected, the fatter you become.