Hypofractionated squamous cell carcinoma of thymus is a type of thymic cancer with high malignant degree, which needs standardized treatment, and the main treatment options include surgical resection, radiotherapy, chemotherapy and targeted therapy. 1. Surgical resection: Generally speaking, if the lesion is relatively early and has no obvious invasion to the surrounding tissues, radical resection can be chosen. 2. Radiotherapy: used for adjuvant treatment after surgery or in cases where surgical resection is not possible, radiotherapy can be chosen, mainly choosing local radiotherapy, and commonly used drugs for chemotherapy include cyclophosphamide and paclitaxel. 3. Targeted drug therapy: for patients with gene mutation, they can choose to do targeted therapy, commonly used drugs include sorafenib. When low-differentiated squamous cell carcinoma of thymus is found, it should be hospitalized in time, and after diagnosing the disease, standardized treatment should be carried out under the guidance of clinicians.