The disappearance of lesions after targeted drug treatment does not mean cure, malignant tumors have the possibility of recurrence, and targeted drugs are prone to drug resistance. Clinical assessment of tumor cure is generally based on the five-year tumor-free survival period, after effective treatment, the tumor completely disappeared, and there is no recurrence within five years can be called clinical cure. The disappearance of lesions after targeted drug treatment can only represent the temporary effectiveness of targeted therapy, which cannot be called a complete cure. Malignant tumors have the possibility of recurrence, and some patients will have drug resistance, which will lead to tumor recurrence. Especially for advanced malignant tumors, even though targeted therapy is temporarily effective, the long-term efficacy is not optimistic, so even if the lesion disappears, we should not take it lightly, and should complete the prescribed treatment cycle under the guidance of the doctor, and review regularly to prevent recurrence.