There is no such thing as the most effective way to get rid of blackheads, and it needs to be treated in conjunction with the cause of the disease. If there is excessive sebum secretion, topical medication is usually chosen; if Propionibacterium acnes is proliferating, systemic medication can be used; if the keratinization of follicular sebaceous gland ducts is more serious, physical treatment can be chosen. 1. Excessive sebum secretion: Excessive sebum secretion may form blackheads, and in severe cases, it may increase inflammation leading to acne, and topical medications, such as adapalene and isotretinoin, are generally available. 2. Propionibacterium acnes proliferation: In order to effectively improve the anaerobic environment of the hair follicle and minimize the propagation of Propionibacterium acnes, oral isotretinoin can be taken, and if acne is more serious, antibiotics can be chosen, such as doxycycline, minocycline and so on. 3. Abnormal keratinization of follicular sebaceous gland ducts: If the blackheads are more serious, you can choose physical treatment, for example, you can choose fruit acid peeling, which can effectively exfoliate, achieve the effect of oil control, reduce blackheads and prevent blackheads. Although there are many ways to remove blackheads, each person’s situation is not exactly the same and requires individualized treatment. It is recommended that patients go to a regular hospital for treatment in a timely manner, and at the same time pay attention to the use of drugs need to follow the doctor’s instructions.