[Abstract] Objective To evaluate the effect of dexmedetomidine compound anesthesia on agitation during the awakening period in children with cerebral palsy surgery. Methods Fifty children with cerebral palsy who underwent elective muscle strength and tone adjustment, aged 2-12 years, weighing 10-52 kg, with ASA classification grade I-II. The children were randomly divided into 2 groups, dexmedetomidine group (Group D) and control group (Group C), with 25 cases in each group, using the random number table method. The anesthesia was induced by intravenous midazolam 0.1 mg/kg, sufentanil 0.3ug/kg, cisatracurium 0.15 mg/kg and propofol 2 mg/kg, and mechanical ventilation was performed after tracheal intubation. dexmedetomidine 0.5ug/kg was pumped intravenously within 15 min after tracheal intubation in group D, and equal volume of saline was pumped in group C. The changes of heart rate and blood pressure, ETsev%, PAED, time of awakening, time of extubation, and blood glucose and cortisol concentrations at different time points were recorded during anesthesia. cortisol concentrations at different time points. The results showed that compared with group C, group D showed a decrease in sevoflurane dosage and ETsev% at T2 and T3, a decrease in blood glucose and cortisol concentration at T4 (P < 0.01), a shortening of awakening time and dialing time (P < 0.05 or < 0.01), and a significant decrease in PAED score (P < 0.01) during anesthesia. Conclusion Dexmedetomidine compound anesthesia can reduce the stress response, decrease muscle tone, shorten the awakening time and dialing time, and prevent agitation during the awakening period of general anesthesia in children undergoing cerebral palsy surgery. 【Key words】Dexmedetomidine; sevoflurane; agitation during waking period; cerebral palsy; pediatric