Hard bumps in the crack of the toes that hurt when pressed can be caused by corns, plantar warts, and gout stones. 1. corns: hard bumps in the toe crevice that hurt when pressed may be caused by corns. Chicken eye is long-term friction and pressure-induced hyperplasia of the stratum corneum to form a keratinous embolus, due to its root deeply embedded in the flesh, the top of the formation of hard knots. When walking or squeezing, pain can occur. 2. metatarsal warts: the hard bumps in the toes can be painful when pressed, but they can also be caused by metatarsal warts. The plantar warts are infected with the human papilloma virus causing the foot to appear benign superfluous organisms, mainly manifested in the sole of the foot with keratinized pimples or plaques, and long-term pressure can be accompanied by oppressive pain. 3. Gouty stones: toes seam long hard bumps will be painful to press may also be caused by gouty stones, uric acid excretion disorders and (or) purine metabolism disorders can lead to gout, the main manifestations of recurrent joints, redness, swelling, pain, gouty stones and so on. There are many reasons why the hard bumps in the toe crevice will hurt when pressed, it is recommended to go to the hospital in time, under the guidance of the doctor to carry out active treatment.