Bone metastasis of hepatocellular carcinoma refers to the metastasis of hepatocellular carcinoma cells to bone tissues, and patients will manifest bone pain and pathological fracture, etc., which need to receive timely treatment under the guidance of doctors. Hepatocellular carcinoma bone metastasis refers to the tumor cells being transported to bone marrow through blood and lymphatic system, and malignant proliferation in bone marrow causes bone pain and pathological fracture, and the appearance of bone metastasis suggests that the disease has progressed into advanced stage. Generally, radiotherapy, chemotherapy and targeted therapy are recommended. Commonly used chemotherapeutic drugs include vincristine, cyclophosphamide, fluorouracil, cisplatin, etc. Commonly used targeted drugs include sorafenib and lenvatinib, etc. The drugs need to be used according to the doctor’s prescription, and it is recommended to consult the doctor if any adverse reaction occurs. After standardized treatment, tumor lesions can be effectively reduced, clinical symptoms relieved, quality of life of patients improved and survival time prolonged.