If a patient experiences severe pain from a mouth ulcer, pain relievers such as compounded acetaminophen tablets or ibuprofen extended-release tablets can be taken orally to relieve symptoms. Mouth ulcers are a kind of ulcerative damage disease that occurs on the oral mucosa due to many reasons, and there is no specific drug that can cure mouth ulcers. Oral pain medication for the treatment of oral ulcers clinical effect compared to the external application of drugs and bulk is relatively worse, so the treatment is generally used ice boron powder, watermelon cream spray, vitamin B2 powdered coating on the affected area. Patients with severe mouth ulcers that cause severe pain can choose to take oral acetaminophen tablets or ibuprofen extended-release tablets and other painkillers to relieve pain. Mouth ulcers have a variety of causes and are prone to recurrence, and are generally treated with topical medications for faster results, and oral pain medications can be taken for the two mentioned above for severe cases. Can treat mouth ulcers more kinds of drugs, it is recommended that patients with mouth ulcers to the regular hospital stomatology clinic for treatment, follow the doctor’s instructions to use the drug, not blindly self medication.