Personal protection, hand hygiene and routine preventive disinfection need to be strengthened during the new crown outbreak. First of all, the new coronavirus is mainly caused by the new coronavirus, and its main sources of infection are confirmed cases of new coronavirus pneumonia and asymptomatic infected people. The virus can be transmitted through respiratory droplets and close contact, and infection can also be caused by contact with objects contaminated with the virus. Aerosolized transmission is also possible, especially in densely populated areas exposed to high concentrations of aerosols. Currently, the most effective measure to prevent infection with C. neoformans is vaccination against C. neoformans. However, the risk of infection still exists as vaccination is not 100% effective in preventing infection. In order to avoid the spread of the virus by the above means in our daily life, we need to develop the habit of wearing masks, especially in and out of crowded and unventilated places, we must wear masks scientifically. Do not touch suspicious surfaces in public places, and pay attention to hand hygiene before and after meals. It is also necessary to strengthen the preventive disinfection work in the family and workplace. As far as possible to reduce the chance of contact with pathogens. Tip: “New coronavirus pneumonia” and “new coronavirus pneumonia” mentioned in this article were renamed to “new coronavirus infection” on December 26, 2022, as announced by the National Health Commission.