Positive Legionella pneumophila generally refers to Legionella pneumophila, need to be actively consulted and treated, the common treatment methods include general treatment, drug treatment, etc., it is recommended to listen to the professional doctor’s advice, the use of medication to follow the doctor’s instructions. 1. General treatment: If the person is infected with Legionella because of taking immunosuppressants, he should stop using them as much as possible. For those who are hypoxic, oxygen should be administered in time, and mechanical ventilation should be used if necessary to actively correct hypoxemia. If there is acid-base imbalance, water or electrolyte imbalance, it is necessary to timely and actively correct, such as rehydration, replenishment of electrolytes, etc., and regularly monitor the indicators, dynamic adjustment. Patients should have a light diet and strengthen rest. 2. Drug therapy: early application of effective antibacterial drug therapy is the key, preferred new macrolides, quinolones, such as azithromycin or levofloxacin. Patients with severe pneumonia may not be effective with antibiotics alone, and joint application may be considered. The use of medication should be individualized to select the appropriate antibiotics, the specific use of drugs need to follow the doctor’s instructions. Patients with positive Legionella pneumophila pneumoniae need to be treated promptly and actively to avoid delays.