Alkaline phosphatase, commonly abbreviated as ALP, is produced mainly in the liver and in an alkaline environment can hydrolyze various naturally occurring phosphate monolipid compounds, which are excreted through the hepatic biliary system. It is a good indicator of bile duct obstruction, intrahepatic occupying lesions, etc. When the liver is damaged or obstructed, it enters the bloodstream via the lymphatic tract and hepatic sinusoids, and also causes a significant increase in serum alkaline phosphatase due to impaired bile excretion from the intrahepatic biliary tract and backflow into the blood. The causes of high alkaline phosphatase can be divided into physiological and pathological causes, as discussed below: 1. Physiological causes Children’s skeletal development, pregnant women, and fracture healing period, the alkaline phosphatase in bone tissue is very active in these cases, so the value will be high when tested. 2, pathological causes When the body suffers from obstructive jaundice, primary liver cancer, secondary liver cancer, cholestatic hepatitis, etc., the liver cells overproduce ALP, which enters the bloodstream through the lymphatic tract and liver sinusoids, and at the same time, due to impaired bile excretion, backflow into the blood, causing high alkaline phosphatase in serum. 3, bone For example, rickets, bone tumors, chondromalacia, etc. 4, other such as kidney disease, severe anemia, thyroid insufficiency, leukemia, etc.