Local drug therapy for vitiligo on scrotum mainly includes glucocorticoid preparations, calcium-modulated phosphatase inhibitors, vitamin D3 derivatives and so on. 1. Glucocorticoid preparations: including dexamethasone, hydrocortisone and so on. However, it is necessary to pay attention to the adverse effects such as skin atrophy and capillary dilatation caused by long-term local use. 2. Calcium-modulated phosphatase inhibitors: including tacrolimus ointment, pimecrolimus cream and so on. Applicable to adults and children, especially the thin and tender parts of skin mucosa. 3. Vitamin D3 derivatives: including Calcipotriol and Tacalcitol ointment. The use of specific drugs should be under the guidance of a doctor. If there is any discomfort, it is recommended to seek medical advice and treatment promptly.