The main mechanism of proton pump inhibitors for upper gastrointestinal bleeding is: inhibit hydrogen, potassium, adenosine triphosphatase on the wall cells of the gastric mucosa, so as to achieve the purpose of inhibiting the secretion of gastric acid, so that the acidity of the stomach is weakened, neutral or alkaline environment, the general blood components are easy to coagulate in the neutral or slightly alkaline environment, so that it can play an indirect hemostasis effect, and at the same time, reduce the corrosion of gastric acid on the stomach.
Proton pump inhibitors include rabeprazole, omeprazole, pantoprazole, lansoprazole, esomeprazole, etc. In addition to being used for upper gastrointestinal bleeding, they can also be used for gastric ulcers, duodenal ulcer disease, gastroesophageal reflux disease and chronic gastritis.
Patients should take proton pump inhibitors under the guidance of a physician to prevent nausea, flatulence, diarrhea, constipation, epigastric pain, rash, liver function abnormalities, etc. Allergic to proton pump inhibitors, severe renal insufficiency, and infants and young children are prohibited, and should not be able to be used in combination with atazanavir.
Usually pay attention to light diet, do not smoke and drink alcohol, do not overeat, patients with gastrointestinal bleeding, should go to the hospital in a timely manner, pay attention to hemostasis and rehydration, to prevent the emergence of blood volume insufficiency and life-threatening. The medication should be administered under the guidance of a doctor.