Leg and wrist pain like twisting may be caused by aseptic inflammation or acute attack of gout. 1. Aseptic inflammation: aseptic inflammation is an inflammatory reaction caused by various non-biological factors, daily if overworked, the leg and wrist will be in a state of chronic strain, which will cause aseptic inflammation, resulting in redness, swelling, heat, pain, dysfunction and other symptoms. 2. Lower extremity soft tissue infection: it may also be the soft tissue of the lower extremity is infected by bacteria caused by the ankle pain like twisted, mostly seen in trauma, wound infection, foreign body retention and so on. 3. Acute attack of gout: gout is a disease caused by the deposition of monosodium urate in the body, and purine metabolism disorders, uric acid excretion disorders caused by hyperuricemia directly related. Gout in the acute attack will appear joint redness, swelling, heat, pain, and even affect normal activities. It is recommended to go to the hospital in time, because the cause of the disease is different, the specific treatment will be different.