Flatulence with burning sensation may be related to insufficient gastric motility and excessive secretion of gastric acid, it is recommended to go to the hospital for examination to identify the specific cause. Flatulence with burning sensation can be seen in gastroesophageal reflux disease (GERD), the typical symptoms of acid reflux, heartburn, accompanied by other symptoms such as abdominal pain, bloating, belching and so on. The disease is mainly associated with reflux of gastric contents and long-term damage to the anti-reflux barrier. It can be treated with acid-suppressing drugs such as omeprazole and gastric stimulants such as mosapride, and the symptoms can be gradually relieved. The symptoms can also be seen in gastric ulcers. Gastric ulcers can present with bloating, recurrent and regular episodes of abdominal pain. The cause of the disease may be related to Helicobacter pylori infection, and the treatment can choose drugs to eradicate Helicobacter pylori infection, such as proton pump inhibitors such as omeprazole, antibiotics such as amoxicillin, clarithromycin, and bismuth such as bismuth potassium citrate. It is recommended that the patient consult the doctor in time, improve the examination to clarify the cause of the disease, and then give targeted treatment.