Drinking coffee while taking a cephalosporin is not recommended to avoid affecting the efficacy of the drug. It is not recommended to drink coffee after taking cephalosporin by mouth or using cephalosporin antibiotics by infusion. Coffee contains caffeine, which can stimulate the nervous system and gastrointestinal tract, leading to faster breathing, it is recommended to drink coffee two hours after taking cephalosporin. Note that after oral or infusion of cephalosporin antibiotics, do not drink alcohol, because cephalosporin antibiotics inhibit the activity of acetaldehyde dehydrogenase, can not make the alcohol decomposition, can occur redness, panic, nausea and other disulfiram-like reaction, serious or even life-threatening. Adverse reactions to oral cephalosporin antibiotics, it is recommended that you can consult a regular hospital internist or licensed pharmacist.