Breast ultrasound during menstruation is more accurate in detecting the presence of nodules, and patients need to be treated promptly and reasonably under the guidance of a doctor. Usually, breast ultrasound is the main basis for grading and evaluating breast nodules, and it can make differential diagnosis of breast fibroadenoma, breast hyperplasia and breast cancer according to the shape of the patient’s breast nodules, cysticity, and the relationship with the surrounding tissues. Breast ultrasound examination during menstruation is also more accurate, and if patients are found to have breast nodules, they need to seek medical treatment in time. Generally, benign breast nodules do not require surgical treatment and regular observation is sufficient. However, for patients whose nodules grow rapidly, seriously affect the appearance and feel of the breast, or have a tendency of malignant changes, they need to undergo surgery under the guidance of a doctor in a timely manner. It is recommended that patients who have breast ultrasound during menstruation and find a nodule, according to the degree of their own condition, actively carry out targeted treatment.