Low platelets on chemotherapy need to be evaluated for etiology first, and platelet transfusions, platelet growth factors, etc. should be given if necessary. The medication should follow the doctor’s instructions. 1. Evaluation of etiology: Commonly, such as oxaliplatin chemotherapy, etc., need to assess the etiology and condition of the disease, and whether to change the chemotherapeutic drugs by a professional physician. 2. Drug treatment: (1) Platelet transfusion: the fastest and most effective way to treat severe low platelet count, platelet count ≤ 10×10^9 /L, need to preventive platelet transfusion, if combined with certain conditions, such as active hemorrhage solid tumors, cranio-cerebral surgery, etc., transfusion indications can be appropriately relaxed. Pay attention to the complications of platelet transfusion, such as fever, DIC and so on. (2) Platelet growth factor: common platelet cytokine drugs include recombinant human interleukin-11, rhIL-11 derivatives and recombinant human thrombopoietin, etc. Pay attention to the adverse effects of drugs. Low platelet counts after chemotherapy require prompt diagnosis and treatment to avoid adverse effects. Drugs should be used under the guidance of a doctor, avoid self-medication.