Symptoms of advanced hairy cell leukemia include infection, anemia, bleeding, nausea, vomiting, abdominal distension caused by an enlarged spleen, and some patients may even experience generalized pain. Hairy cell leukemia is a rare type of leukemia in clinic, characterized by enlarged spleen and decreased whole blood cells, and the above symptoms will be significantly aggravated in the advanced stage. 1. Abnormal enlargement of the spleen can lead to nausea, vomiting and abdominal distension. 2. Pancytopenia can lead to infections, anemia, and a series of bleeding events, such as severe lung infections and organ hemorrhages, which can be life-threatening. 3. In addition, in the advanced stage of hairy cell leukemia, there may be generalized pain, such pain is often more severe, the general effect of pain medication is not satisfactory, the need to apply strong painkillers such as morphine, etc., must be used under the guidance of a physician. Diagnosis and treatment should be carried out under the supervision of a physician.