The difference between milk café au lait spots and birthmarks is that milk café au lait spots are a type of birthmark and may have neurofibromatosis complications. Birthmarks belong to a more general term, including pigmented birthmarks (Mongolian spots, nevus of Ota, milk coffee spot and congenital pigmented nevus) and vascular birthmarks (cavernous hemangioma, nevus erythematosus, strawberry hemangioma), etc. The reason for its formation is related to the abnormalities of the skin tissues, which normally will not affect the body and do not need to carry out too much treatment. Coffee milk nevus belongs to a special type of birthmarks. When the size and number of coffee milk nevus continue to increase, it is necessary to consider the possibility of neurofibroma at the same time. Neurofibroma is a kind of tumor with certain malignant tendency, and it is also a kind of congenital autosomal dominant hereditary skin disease. Prolonged exposure to radiation and exposure to contaminated environments are the main triggers for neurofibromas. As the two belong to the inclusion of the relationship, so the two have a certain degree of similarity, the specific circumstances need to go to the regular medical institutions to ask the specialist doctor for an interview, symptomatic treatment.