Headache caused by sinusitis can take antibiotic drugs (such as cefuroxime, amoxicillin clavulanate potassium, etc.) and drugs for pain (such as ibuprofen, diclofenac sodium, etc.). 1. Drugs for sinusitis: If the sinusitis is caused by bacterial infection, it is necessary to use sufficient amount of antibiotics to control the infection treatment, you can choose penicillin (such as amoxicillin clavulanate potassium), cephalosporins (such as cefuroxime), macrolide toxicity (Clarithromycin) and other anti-infective treatment. 2. Painkillers: If the headache caused by sinusitis seriously affects your life and work, you can use non-steroidal anti-inflammatory drugs such as ibuprofen and diclofenac sodium for pain relief. The use of non-steroidal anti-inflammatory drugs need to pay attention to peptic ulcer patients with caution. In addition to oral medications, nasal glucocorticoids, such as mometasone furoate nasal spray, can be administered; nasal irrigation with saline. If there is sinusitis with headache, it is recommended to go to the hospital in a timely manner to diagnose and standardize the use of medication and treatment.