The duration of creatinine 160 μmol/L is related to the cause of creatinine elevation, the effect of treatment, etc., and there are individual differences in the maintenance time. Creatinine is one of the key indicators used to determine kidney function. Its normal value is 53~106μmol/L for men and 44~97μmol/L for women. Elevated creatinine can be generally categorized into physiological and pathological causes. Physiological causes such as strenuous exercise, excessive meat consumption, etc. can cause creatinine elevation, usually after the elimination of the triggering factors, creatinine can gradually return to normal, and the elevation will not last for a long time. Pathological factors such as acute kidney injury caused by drugs or other reasons, usually after the elimination of triggering factors and active treatment, creatinine can be normalized. If chronic nephritis causes creatinine 160μmol/L, usually after active treatment, creatinine may be maintained at this level for months~years, and clinically it can be seen that patients who maintain it for decades, and there are individual differences in the maintenance time. If the examination found creatinine 160μmol / L, it is recommended to cooperate with a professional doctor as soon as possible to improve the next step of the examination, to clarify the cause, timely targeted treatment to avoid the development of the disease.