Whether creatinine can rise after poor sleep is related to the patient’s own condition. If the patient has no kidney disease, poor sleep usually does not lead to creatinine increase; if the patient has kidney disease, poor sleep may increase the burden on the kidneys, which may lead to creatinine increase. Creatinine is the metabolic end product of creatine in muscle tissue. Creatinine does not bind with protein in the blood and can pass freely through the glomerulus, which is the most commonly used indicator to indirectly reflect the glomerular filtration function. When the renal parenchyma is damaged and the glomerular filtration rate is reduced, the blood creatinine concentration will rise significantly. If the patient has no previous kidney disease, poor sleep usually does not lead to elevated creatinine, but it is recommended that the patient improve the quality of sleep; if the patient has kidney disease, poor sleep may aggravate the burden on the kidneys, which may lead to elevated creatinine. If patients find that the creatinine is elevated, it is recommended to go to regular hospitals in a timely manner, improve the examination to clarify the cause of the disease, and then give targeted treatment or therapy under the guidance of the doctor.