Oxygen intake in patients with chronic obstructive pulmonary disease should pay attention to long-term home oxygen therapy and low-flow oxygen intake. 1. Long-term home oxygen therapy: long-term home oxygen therapy can be practiced for patients in the stabilization period. Oxygen intake time should be more than 15 hours per day, which can improve the quality of life and survival rate of those with chronic respiratory failure complicated by chronic obstructive pulmonary disease, and will have beneficial effects on hemodynamics, exercise capacity and mental status. 2. Low-flow oxygen: In acute exacerbation, those who develop hypoxemia can use nasal catheter oxygen, or oxygen through a venturi mask. Nasal catheter oxygenation, the oxygen concentration of patients with chronic obstructive pulmonary disease is generally 28% to 30% of the most appropriate, the oxygen flow rate is generally 1~2L/min, to avoid carbon dioxide retention caused by too high a concentration of inhaled oxygen. If the high flow of oxygen, although it can solve the hypoxia, but the brain will be anesthetized by carbon dioxide, but will make the respiratory weakening, and even heartbeat. Patients with chronic obstructive pulmonary disease (COPD) have long-term chronic cough, shortness of breath, dyspnea and other clinical manifestations. If the patient is in a state of long-term hypoxia, it will lead to coma, brain death, respiratory arrest and other serious consequences, so oxygen therapy is particularly critical. Patients should be treated under the guidance of a doctor to avoid adverse consequences.