Follicular Impermeability Syndrome (FIS), also known as Follicular Luteinization Syndrome (FLS), is a syndrome in which mature follicles fail to rupture due to a variety of reasons and the eggs are unable to be discharged, resulting in failure to conceive. The most common cause of follicular failure syndrome in women is central endocrine dysfunction. When central endocrine dysfunction occurs, it affects follicular growth and development and the occurrence of ovulation, which in turn affects normal conception. The treatment of this disease is generally based on inducing ovulation, and the most common method is to use some ovulation-promoting drugs to help ovulation, such as clomiphene citrate. The causes of follicular luteinization syndrome need to be judged on a case-by-case basis, and it is recommended that when women experience infertility symptoms, they should go to a specialist hospital for a detailed examination, a clear diagnosis, and symptomatic treatment.